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Basal cell carcinoma of the skin often contains mutations of the p53 gene and the gene called PTCH (mutated in congenital nevoid basal cell carcinoma syndrome) . These mutations are most likely the result of action of which of the following?


A) Epidermal growth factor
B) G-protein signal transduction system
C) Chemical carcinogens from the environment
D) Ultraviolet light
E) Cosmic radiation

F) C) and D)
G) A) and B)

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D

Which of the following skin lesions becomes darker and more pigmented upon exposure to sunlight?


A) Vitiligo
B) Lentigo
C) Ephelis
D) Congenital melanocytic nevus
E) Dysplastic nevus

F) None of the above
G) A) and D)

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C

A well-demarcated, coin-like, dark brown lesion appeared on the shoulder of a 59-year-old man. The lesion appears velvety, greasy, and has a "stuck on" appearance so that it can easily be removed. Which of the following is the most likely diagnosis? A well-demarcated, coin-like, dark brown lesion appeared on the shoulder of a 59-year-old man. The lesion appears velvety, greasy, and has a  stuck on  appearance so that it can easily be removed. Which of the following is the most likely diagnosis?   A)  Lentigo B)  Ephelis C)  Vitiligo D)  Seborrheic keratosis E)  Actinic keratosis


A) Lentigo
B) Ephelis
C) Vitiligo
D) Seborrheic keratosis
E) Actinic keratosis

F) C) and D)
G) A) and B)

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Which of the following skin lesions will most likely progress to invasive squamous cell carcinoma?


A) Actinic keratosis
B) Seborrheic keratosis
C) Seborrheic dermatitis
D) Epidermal inclusion cyst
E) Steatocystoma multiplex

F) A) and B)
G) A) and C)

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A

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