Question 1

After exercise, muscle cell glycogen metabolism is regulated by:

Accepted Answer

A)   insulin.
B)   phosphorylase a.
C)   glucagon.
D)   glycogen synthase.
E)   protein phosphatase 1.F) A) and C)
G) A) and E)

Question 2

The reaction catalyzed by __________________ transfers UDP-glucose to the hydroxyl of an existing glycogen core.

Accepted Answer

A)  UDP-glucose
B)  nonreducing
C)  synthesis
D)  glucose
E)  glycogeninF) Von Gierke diseaseG) glycogen synthaseH) UTP-glucoseI) protein phosphatase 1 (PP1) J) PPiK) glycogen phosphateL) McArdle diseaseM) E) and L)
N) A) and G)

Question 3

Which of the following occur after a carbohydrate-rich meal?

Accepted Answer

A)   Blood-glucose levels increase, leading to glycogen storage in the liver.
B)   Blood-glucose levels increase, leading to glycogen storage in the muscle.
C)   Glycogen storage in the muscle shuts down.
D)   All of the above.
E)   None of the above.F) A) and B)
G) All of the above

Question 4

The enzyme that begins the kinase cascade, activating glycogen degradation, is:

Accepted Answer

A)   glycogen synthase.
B)   phosphorylase kinase.
C)   PKC.
D)   PKA.
E)   tyrosine kinase.F) A) and E)
G) B) and E)

Question 5

The complete oxidation of a glucose residue from glycogen produces ________________ ATP.

Accepted Answer

The answer of The complete oxidation of a glucose residue...

Question 6

In general, phospho- forms of glycogen synthase lead to ________________ levels of glycogen.

Accepted Answer

The answer of In general, phospho- forms of glycogen synthase...

Question 7

Explain how the formation of UDP-glucose from glucose 1-phosphate and UTP is essentially reversible.

Accepted Answer

The hydrolysis of pyrophosphate (PPi) to...

Question 8

An incorrect, tight binding of PP1 to glycogen synthase would result in:

Accepted Answer

A)   a hyperactive glycogen synthase.
B)   hyper-glycogen levels.
C)   increased insulin action.
D)   high blood glucose.
E)   activated glycogen synthase.F) A) and B)
G) A) and C)

Question 9

__________________ is is a primer that polymerizes the first few glucose molecules.

Accepted Answer

A)  UDP-glucose
B)  nonreducing
C)  synthesis
D)  glucose
E)  glycogeninF) Von Gierke diseaseG) glycogen synthaseH) UTP-glucoseI) protein phosphatase 1 (PP1) J) PPiK) glycogen phosphateL) McArdle diseaseM) G) and K)
N) B) and G)

Question 10

_______________ is the key regulatory enzyme in glycogen synthesis.

Accepted Answer

A)  UDP-glucose
B)  nonreducing
C)  synthesis
D)  glucose
E)  glycogeninF) Von Gierke diseaseG) glycogen synthaseH) UTP-glucoseI) protein phosphatase 1 (PP1) J) PPiK) glycogen phosphateL) McArdle diseaseM) E) and L)
N) F) and J)

Question 11

_______________ is the glycogen storage disease in which the defective enzyme is glucose 6-phosphatase.

Accepted Answer

A)  UDP-glucose
B)  nonreducing
C)  synthesis
D)  glucose
E)  glycogeninF) Von Gierke diseaseG) glycogen synthaseH) UTP-glucoseI) protein phosphatase 1 (PP1) J) PPiK) glycogen phosphateL) McArdle diseaseM) F) and J)
N) A) and G)

Question 12

Explain how the liver responds to muscle challenges in insulin-dependent diabetes.

Accepted Answer

The liver primarily ...

Question 13

The activated glucose donor of glycogen synthesis is:

Accepted Answer

A)   glucose 1-phosphate.
B)   glucose.
C)   ATP.
D)   UTP.
E)   None of the above.F) A) and B)
G) A) and C)

Question 14

Which is the true glucose-level sensor in the cell?

Accepted Answer

A)   insulin
B)   phosphorylase a
C)   glucagon
D)   glycogen synthase
E)   protein phosphatase 1F) A) and D)
G) A) and E)

Question 15

Explain why Type I diabetes is often called "fasting in the sea of plenty."

Accepted Answer

The muscle cell is not able to transport...

Question 16

The __________________ creates a 1,6-glycosidic bond.

Accepted Answer

A)   branching enzyme
B)   glucose transferase
C)   glycogen isomerase
D)   glycogen synthase
E)   None of the above.F) C) and D)
G) A) and B)

Question 17

How are new glucosyl units added to a growing glycogen molecule?

Accepted Answer

Glucosyl units are added to th...

Question 18

There is a high __________________-to-insulin ratio in diabetes.

Accepted Answer

The answer of There is a high __________________-to-insulin ratio in...

Question 19

Give the reaction catalyzed by UDP-glucose pyrophosphorylase.

Accepted Answer

Glucose 1-...

Question 20

Glycogen synthase is converted into the active form by the action of __________________.

Accepted Answer

protein ph...

Exam 25: Glycogen Synthesis

Explain why Type I diabetes is often called "fasting in the sea of plenty."

Correct AnswerverifiedThe muscle cell is not able to transport...View AnswerShow Answer

__________________ is is a primer that polymerizes the first few glucose molecules.

Correct AnswerverifiedShow Answer

Explain how the liver responds to muscle challenges in insulin-dependent diabetes.

Correct AnswerverifiedThe liver primarily ...View AnswerShow Answer

The complete oxidation of a glucose residue from glycogen produces ________________ ATP.

Correct AnswerverifiedShow Answer

The __________________ creates a 1,6-glycosidic bond.

Correct AnswerverifiedShow Answer

_______________ is the key regulatory enzyme in glycogen synthesis.

Correct AnswerverifiedShow Answer

Explain how the formation of UDP-glucose from glucose 1-phosphate and UTP is essentially reversible.

Correct AnswerverifiedThe hydrolysis of pyrophosphate (PPi) to...View AnswerShow Answer

How are new glucosyl units added to a growing glycogen molecule?

Correct AnswerverifiedGlucosyl units are added to th...View AnswerShow Answer

An incorrect, tight binding of PP1 to glycogen synthase would result in:

Correct AnswerverifiedShow Answer

Which is the true glucose-level sensor in the cell?

Correct AnswerverifiedShow Answer

The reaction catalyzed by __________________ transfers UDP-glucose to the hydroxyl of an existing glycogen core.

Correct AnswerverifiedShow Answer

Glycogen synthase is converted into the active form by the action of __________________.

Correct Answerverifiedprotein ph...View AnswerShow Answer

_______________ is the glycogen storage disease in which the defective enzyme is glucose 6-phosphatase.

Correct AnswerverifiedShow Answer

Which of the following occur after a carbohydrate-rich meal?

Correct AnswerverifiedShow Answer

Give the reaction catalyzed by UDP-glucose pyrophosphorylase.

Correct AnswerverifiedGlucose 1-...View AnswerShow Answer

The activated glucose donor of glycogen synthesis is:

Correct AnswerverifiedShow Answer

The enzyme that begins the kinase cascade, activating glycogen degradation, is:

Correct AnswerverifiedShow Answer

There is a high __________________-to-insulin ratio in diabetes.

Correct AnswerverifiedShow Answer

After exercise, muscle cell glycogen metabolism is regulated by:

Correct AnswerverifiedShow Answer

In general, phospho- forms of glycogen synthase lead to ________________ levels of glycogen.

Correct AnswerverifiedShow Answer

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The muscle cell is not able to transport...
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The liver primarily ...
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The hydrolysis of pyrophosphate (PPi) to...
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Glucosyl units are added to th...
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protein ph...
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Glucose 1-...
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